ASSOCIATION OF THE PRESENCE OF BCR-ABL1 GENE REARRANGEMENTS AND MYELOID ABERRANT ANTIGENS IN PRECURSOR B-ACUTE LYMPHOBLASTIC LEUKEMIA (PRE-B-ALL) PATIENTS

Authors

  • Ayesha Younas Chughtai Institute of Pathology, Lahore Pakistan
  • Isma Imtiaz Chughtai Institute of Pathology, Lahore Pakistan
  • Mohammad Jamil Awan Chughtai Institute of Pathology, Lahore Pakistan
  • Ayisha Imran Chughtai Institute of Pathology, Lahore Pakistan
  • Touqeer Nazir Chughtai Institute of Pathology, Lahore Pakistan
  • Noman Aslam Malik Chughtai Institute of Pathology, Lahore Pakistan

DOI:

https://doi.org/10.55629/pakjpathol.v34i4.786

Abstract

Objective: To determine the association of the presence of BCR-ABL1 gene rearrangements and myeloid aberrant antigens in precursor B-ALL patients.

Material and Methods: Both males and females, of all age groups, diagnosed with precursor B-ALL on flow cytometry were included in the study. BCR-ABL1 gene rearrangement was identified by performing Fluorescence in situ hybridization (FISH) using Vysis LSI BCR/ABL, Dual color, Dual fusion translocation probe set. The results were noted and compared with the results of flow cytometry.

Results: Male patients were 36 (60%) and female patients were 24 (40%) out of total 60 patients. Median age was 22 years (range 1-73). BCR-ABL1 fusion gene was identified in 47 (78%) patients while 13 (22%) patients were negative for BCR-ABL1. Aberrant myeloid antigens were expressed in 24 (40%) patients and all of these patients were BCR-ABL1 positive. None of BCR-ABL1 negative patients expressed aberrant antigens. There was statistically significant association between BCR-ABL1 positivity and CD117 expression (P<0.05).

Conclusion: 

Keywords: BCR-ABL1, Pre B-ALL, Myeloid aberrant antigens, Flow cytometry, FISH.

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Published

29-12-2023

How to Cite

1.
Younas A, Imtiaz I, Awan MJ, Imran A, Nazir T, Malik NA. ASSOCIATION OF THE PRESENCE OF BCR-ABL1 GENE REARRANGEMENTS AND MYELOID ABERRANT ANTIGENS IN PRECURSOR B-ACUTE LYMPHOBLASTIC LEUKEMIA (PRE-B-ALL) PATIENTS . Pak J Pathol [Internet]. 2023 Dec. 29 [cited 2024 Dec. 22];34(4):118-23. Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/786

Issue

Vol. 34 No. 4 (2023): PAKISTAN JOURNAL OF PATHOLOGY

Section

Articles

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Copyright (c) 2024 Ayesha Younas, Isma Imtiaz, Mohammad Jamil Awan, Ayisha Imran, Touqeer Nazir, Noman Aslam Malik

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