CORRELATION OF ER, PR, AND HER2 WITH HISTOLOGICAL GRADES OF INVASIVE DUCTAL CARCINOMA OF BREAST

Authors

  • Yusra Saleem PNS Shifa Hospital, Karachi Pakistan
  • Hina Wasti Bahria University and Heath Sciences, Karachi Pakistan
  • Beenish Hussain Nomani Hamdard University Dental Hospital, Karachi Pakistan
  • Misbah Riaz Bahria University and Heath Sciences, Karachi Pakistan
  • Shaista Bakhat Bahria University and Heath Sciences, Karachi Pakistan
  • Hira Faisal Bahria University and Heath Sciences, Karachi Pakistan

DOI:

https://doi.org/10.55629/pakjpathol.v34i4.761

Abstract

Objective: To study the correlation of histological grades of breast cancer with the expression of hormone receptors ER, PR, and HER2/neuin patients of invasive ductal carcinoma breast.

Material and Methods: A Descriptive, cross-sectional was conducted at the Department of Pathology, PNS Shifa Hospital, Karachi from 13th February 2021 to 12th August 2021.77 cases of invasive ductal carcinoma breast were included in this study with subjects falling between the age groups of 25 and 85. On H&E-stained sections, The Nottingham Scarff Bloom Richardson System variant was used to grade the histology of the samples. The formalin-fixed paraffin-embedded (FFPE) tissues were subjected to immunohistochemistry for ER, PR, and HER-2 receptors using the DAKO Envision kit.

Results: In our study, histological grading of invasive ductal carcinoma was found to be as follows; grade I in 01 (1.30%), grade II in 53 (68.83%), and grade III in 23 (29.87%) patients. Among the hormone receptors, the ER receptors revealed non-significant correlation i.e. 0.090. Also, PR receptors revealed 0.192 and HER-2 showed 0.410 values respectively in accordance to the grades of invasive breast carcinoma.

Conclusion: According to the study's findings, grade II (75.71%) and grade III (22.86%) had the highest prevalence among invasive ductal carcinoma cases. Additionally, the estrogen receptor (ER) expression was higher than that of HER-2 and the progesterone receptor (PR).

Keywords: Histologic grade, Invasive ductal carcinoma, ER, PR, HER-2.

Downloads

Published

29-12-2023

How to Cite

1.
Saleem Y, Wasti H, Nomani BH, Riaz M, Bakhat S, Faisal H. CORRELATION OF ER, PR, AND HER2 WITH HISTOLOGICAL GRADES OF INVASIVE DUCTAL CARCINOMA OF BREAST. Pak J Pathol [Internet]. 2023 Dec. 29 [cited 2026 Oct. 28];34(4):128-32. Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/761

Issue

Vol. 34 No. 4 (2023): PAKISTAN JOURNAL OF PATHOLOGY

Section

Articles

License

Copyright (c) 2024 Yusra Saleem, Hina Wasti, Beenish Hussain Nomani, Misbah Riaz, Shaista Bakhat, Hira Faisal

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Readers may “Share-copy and redistribute the material in any medium or format” and “Adapt-remix, transform, and build upon the material”. The readers must give appropriate credit to the source of the material and indicate if changes were made to the material. Readers may not use the material for commercial purpose. The readers may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.