SIGNIFICANCE OF MEASURING RETICULOCYTE HEMOGLOBIN (RET-HE) IN CHRONIC KIDNEY DISEASE PATIENTS

Authors

  • Isma Imtiaz Chughtai Institute of Pathology, Lahore Pakistan
  • Ayesha Younas Chughtai Institute of Pathology, Lahore Pakistan
  • Ayisha Imran Chughtai Institute of Pathology, Lahore Pakistan
  • Abuzar Siddique Azra Naheed Medical College, Lahore Pakistan
  • Nauman Aslam Malik Chughtai Institute of Pathology, Lahore Pakistan
  • Akhtar Sohail Chughtai Chughtai Institute of Pathology, Lahore Pakistan

DOI:

https://doi.org/10.55629/pakjpathol.v34i2.748

Abstract

Objective: To determine the significance of measuring reticulocyte hemoglobin (Ret-He) in chronic kidney disease patients.

Material and Methods: It was a cross sectional study conducted at Chughtai Healthcare from March 2021 to March 2022. Approval was obtained from the ethical and research committee of the institute. 102 patients, both males and females, between the ages of 10-75 years, diagnosed cases of CKD were included in the study. Informed consent was taken from all the patients. Blood specimens were collected in EDTA vials and serum separating vials and tested for serum iron, serum ferritin, total iron binding capacity (TIBC), transferrin saturation and complete blood count’(CBC). Ret-He was obtained by flowcytometry method using Sysmex XN 1000.  Patients with acute infections/ inflammation, liver diseases, pregnant females, any coexisting bleeding disorder and malignancy were excluded from the study.

Results: There is a significant positive correlation between Iron and Ret-He, a positive correlation between Ret-He and Transferrin saturation and no correlation between Ret-He and ferritin along with TIBC.

Conclusion: Ret-He’ is a reliable and economical test that can be used for detecting iron deficiency, especially in patients with chronic inflammatory conditions such as CKD.

Key Words: Chronic kidney disease (CKD), Reticulated hemoglobin (Ret-He), Iron deficiency anemia

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Published

27-06-2023

How to Cite

1.
Imtiaz I, Younas A, Imran A, Siddique A, Malik NA, Chughtai AS. SIGNIFICANCE OF MEASURING RETICULOCYTE HEMOGLOBIN (RET-HE) IN CHRONIC KIDNEY DISEASE PATIENTS . Pak J Pathol [Internet]. 2023 Jun. 27 [cited 2024 Jul. 22];34(2):37-41. Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/748