MALARIAL INFECTION IN POPULATION OF DISTRICT UMERKOT, SINDH & ITS EFFECTS ON HEMATOLOGICAL PARAMETERS
Objective: To determine the effect of malarial infection on hematological parameters and gender distribution in relation to common parasite of malaria and seasonal variation in population of District Umerkot, Sindh.
Material and Methods: This cross-sectional study was conducted at CMH Chhor from 1st Jan 2019 to 31st Dec 2019 with approval of ethical review committee by IRB certificate number 03/2018. A total number of malaria positive 226 patients with different clinical symptoms of malaria were included and patients with other comorbid and refusal for consent were excluded. All patients with malarial parasite positive peripheral smear were included in the study and also analyzed for Hb, TLC, Platelets, age, gender, species of malarial parasites. The hematological parameters were analyzed using the WHO criteria.
Results: Total 226 malaria positive patients including 200 (88%) males and 26 (12%) females were analyzed with mean age of 33 years (range: 1-75 years). Out of total 226 cases, 215 (95%) were positive for P vivax malaria, 9 (4%) for P. falciparum malaria and 2 (1%) patients for mixed. About 161 (71%) of patients had thrombocytopenia, 70 (31%) had anemia and 28 (12%) patients had leukopenia. July, Aug and Sep had highest number of cases in whole year which also suggest seasonal variation of malaria.
Conclusion: Malarial Infection has significant effect on hematological parameters of patients such as Hb, TLC & Platelets. Plasmodium vivax malaria was more significantly associated with thrombocytopenia whereas Plasmodium falciparum more linked to anemia and leucopenia that can assist in diagnosis and prognosis. Seasonal variation provides important information for strict implementation of preventive measures during high transmission months.
Key Words: Anemia, Hematological parameters, Leukopenia, Malaria, Seasonal variation, Thrombocytopenia.