EFFECT OF INTRAVENOUS CARNITINE ON HEMATOLOGICAL AND RENAL PARAMETERS, ERYTHROPOIETIN DOSE, QUALITY OF LIFE AND CARDIAC FUNCTION IN ESRD PATIENTS AT PNS SHIFA HOSPITAL- A QUASI- EXPERIMENTAL STUDY

Authors

  • Aisha Bibi
  • Sohail Sabir
  • Aamir Ijaz

Abstract

Objectives: To evaluate the influence of carnitine therapy on skeletal myopathy, cardiomyopathy, heart failure, anemia and nutritional markers in an End Stage Renal Disease (ESRD) population.

Design, Setting and Participants: We conducted a prospective cohort study at Nephrology Department, PNS SHIFA, Karachi. A total of 35 patients were included. Blood sampling, two dimensional echocardiography imaging and quality of life (QOL) 36-item short form (SF36) survey was done at baseline, 3 months and at 6 months. At the end of 6 months data was collected and analyzed using SPSS 20.

Results: The age of the subjects was (mean + SD) 46.55 ±16.64 with a male to female ratio of 2:1.There was statistically significant improvement at three and six months in QOL assessment SF36 questionnaire-based Physical Component Summary (PCS) and Mental Component Summary (MCS) (p<0.001 and 0.001), Haematocrit (p<0.02 and 0.004), pre and post dialysis serum urea (p<0.051 and 0.077) and (p<0.037 and 0.278) respectively, Transferrin saturation % (p<0.654 and 0.02), erythropoietin dose reduction per week (p<0.08 and 0.013), Ejection fraction improvement (p<0.104 and 0.023).

Conclusion: Intravenous L-carnitine in our ESRD patients lead to significant effects including improvement in hematological and renal parameters, improvement in cardiac function and quality of life and erythropoietin dose reduction.

Key Words: L-carnitine, Haemodialysis, ESRD, Anemia, quality of life, dialysis adequacy, crdiac function

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Published

03-08-2016

How to Cite

1.
Bibi A, Sabir S, Ijaz A. EFFECT OF INTRAVENOUS CARNITINE ON HEMATOLOGICAL AND RENAL PARAMETERS, ERYTHROPOIETIN DOSE, QUALITY OF LIFE AND CARDIAC FUNCTION IN ESRD PATIENTS AT PNS SHIFA HOSPITAL- A QUASI- EXPERIMENTAL STUDY. Pak J Pathol [Internet]. 2016 Aug. 3 [cited 2024 Mar. 28];24(1). Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/56

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