EFFECT OF INTRAVENOUS CARNITINE ON HEMATOLOGICAL AND RENAL PARAMETERS, ERYTHROPOIETIN DOSE, QUALITY OF LIFE AND CARDIAC FUNCTION IN ESRD PATIENTS AT PNS SHIFA HOSPITAL- A QUASI- EXPERIMENTAL STUDY
Abstract
Objectives: To evaluate the influence of carnitine therapy on skeletal myopathy, cardiomyopathy, heart failure, anemia and nutritional markers in an End Stage Renal Disease (ESRD) population.
Design, Setting and Participants: We conducted a prospective cohort study at Nephrology Department, PNS SHIFA, Karachi. A total of 35 patients were included. Blood sampling, two dimensional echocardiography imaging and quality of life (QOL) 36-item short form (SF36) survey was done at baseline, 3 months and at 6 months. At the end of 6 months data was collected and analyzed using SPSS 20.
Results: The age of the subjects was (mean + SD) 46.55 ±16.64 with a male to female ratio of 2:1.There was statistically significant improvement at three and six months in QOL assessment SF36 questionnaire-based Physical Component Summary (PCS) and Mental Component Summary (MCS) (p<0.001 and 0.001), Haematocrit (p<0.02 and 0.004), pre and post dialysis serum urea (p<0.051 and 0.077) and (p<0.037 and 0.278) respectively, Transferrin saturation % (p<0.654 and 0.02), erythropoietin dose reduction per week (p<0.08 and 0.013), Ejection fraction improvement (p<0.104 and 0.023).
Conclusion: Intravenous L-carnitine in our ESRD patients lead to significant effects including improvement in hematological and renal parameters, improvement in cardiac function and quality of life and erythropoietin dose reduction.
Key Words: L-carnitine, Haemodialysis, ESRD, Anemia, quality of life, dialysis adequacy, crdiac functionDownloads
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Copyright (c) 2016 Aisha Bibi, Sohail Sabir, Aamir Ijaz
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