CORRELATION OF SERUM FERRITIN WITH C-REACTIVE PROTEIN IN IRON DEFICIENCY ANAEMIA
Objective: To find the correlation of serum ferritin as an Acute Phase Reactant with C-Reactive Protein in Iron deficiency Anaemia with underlying inflammatory condition.
Study Design: Comparative cross-sectional study
Place & Period of Study: Department of Chemical Pathology, and Endocrinology CMH Malir Karachi from August 2017 to December 2017.
Method and Material: One hundred and fifty subjects with Iron Deficiency Anaemia (IDA) were enrolled in study. Blood Complete Picture (CP) was analysed on Sysmex Haematology autoanalyzer, Serum Ferritin was analyzed by third generation electrochemiluminescence assay using “Roche autoanalyzer Cobas e-411 and Serum CRP was measured by immunoturbidimetric method. All Participants were divided into three groups on the basis of serum ferritin, Group A had low ferritin (<10 ug/l) n=84(56%), Group B with normal ferritin (11-150 ug/l) n=51(36%) and Group C with high ferritin (>150 ug/l) n=15(10%). All data was analyzed through SPSS version 20. Statistical analysis was performed by Pearson’s correlation tests.
Results. CRP was the highest in group C (mean+SD = 26.34+ 0.34, p< 0.001) and the lowest in group A, (mean+SD = 5.70+0.98, p< 0.001). Contrarily to CRP, Hb was the lowest in group C, (mean+ SD=8.2+0.31, p < 0.001) and the highest in group A, (mean+SD = 10.0+0.73, p < 0.001). Ferritin had a strong positive correlation with CRP (𝑟 = 0.87, p< 0.001) and strong negative correlation with Hb, (𝑟 = -0.67 p < 0.001).
Conclusion. High ferritin level secondary to inflammation may mask an underlying iron deficiency. Serum ferritin was found to be positively correlated with CRP.
Key Words: Serum ferritin, APR, CRP.