URINARY NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN AS A BIOMARKER OF LUPUS NEPHRITIS IN ADULT POPULATION

Authors

  • Hijab Batool Central Park Medical College, Lahore, Pakistan
  • Tahira Naseem Sheikh Zayed Hospital Lahore, Pakistan
  • Marium Shoukat CMH Multan Institute of Medical science, Multan, Pakistan

Abstract

Objective: The purpose of this study was to evaluate the levels of Neutrophil Gelatinase Associated Lipocalin, a tubular stress protein in the urine of diagnosed cases of SLE with and without lupus nephritis.

Study design: Cross sectional analytical study.

Place & Duration of Study: Department of Biochemistry and Chemical Pathology, Sheikh Zayed Hospital Lahore from January 2015 to January 2016.

Materials and methods: Including a total of 84 subjects, 42 cases were SLE without renal involvement and 42 cases were diagnosed cases of SLE with lupus nephritis. The diagnosis of lupus nephritis was established on the basis of renal biopsy.

Results: This study revealed that the nephritis group had increased levels of uNGAL along with increased serum creatinine, increased urinary albumin creatinine ratio and decreased creatinine clearance (CG Formula) as compared to systemic lupus erythematosus patients without having lupus nephritis (p Value <0.05).

Conclusion: ‘These findings clearly indicate that uNGAL levels correlate strongly with the renal components of the disease activity.  Thus, it can be stated that uNGAL can prove to be a noninvasive, reliable and sensitive biomarker to diagnose cases of lupus nephritis.

Key words: Neutrophil gelatinase associated lipocalin, Systemic lupus erythematosus, Lupus nephritis, Biomarker.

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Published

30-10-2017

How to Cite

1.
Batool H, Naseem T, Shoukat M. URINARY NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN AS A BIOMARKER OF LUPUS NEPHRITIS IN ADULT POPULATION. Pak J Pathol [Internet]. 2017 Oct. 30 [cited 2024 Mar. 29];28(3). Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/411

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