MIXED CRYOGLOBULINEMIA – AN IMPORTANT BUT NEGLECTED COMPLICATION IN HEPATITIS C INFECTED PATIENTS
Objective: To highlight the clinical utility, technical ease and resource efficient nature of cryoglobulin test.
Materials and Methods: We present two cases of HCV associated mixed cryoglobulinemia, one presented with skin and renal manifestations and the other one with vague clinical history for whom an extensive workup was carried out for a proper diagnosis.
Results: Recognition of cryoglobulins is crucial for better patient management. Furthermore utility of cryocrit in therapeutic monitoring is worth documenting. The test for cryoproteins is easy to perform with minimal dependence on machines and the technical expertise. The only imperious factor is the temperature control. Correct diagnosis of cryoglobulinemia requires proper temperature regulations during sample handling, quantification and characterization.
Conclusion: It is recommended that all patients with HCV infection must undergo a screening test for cryoglobulins at the time of initial diagnosis to establish the baseline values for further management.
Keywords: Cryoglobulinemia, Cryoglobulins, Hepatitis C