TOXIC EFFECTS OF AEROSOL ADMINISTERED CYPERMETHRIN IN RABBITS
Objective: The study focuses on the toxic effects of Cypermethrin a pesticide in rabbits when administered via aerosol spray through regular conventional nebulizer.
Place and Duration of Study: The study was carried out in the Institute of Environmental Sciences, University of Karachi, during the period of six month from June 2015 till February 2016.
Material & Methods: In this study the dose of the cypermethrin spray was constant but the frequency of administration varied. The pesticide was administered in four different groups of animals i.e. (a) group once daily, (b) group twice a day, (c) group thrice a day and (d) group four times per day, the experiment continued for a period of month there after animals were sacrificed.
Results: The organs such as Brain, Lungs, Kidneys and Liver were dissected and preserved in 10% formalin, it was processed for pathological studies by H&E method.
Conclusions: The observations were recorded on the proforma and to quantify the results a novel scoring system was developed. It was concluded that the dose and frequency dependent injurious changes were observed in Kidneys, Lungs and Liver.Key Words: Cypermethrin, Aerosol, Histopathological changes.