DIFFERENT GRADES OF FIBROSIS IN CHRONIC MYELOPROLIFERATIVE NEOPLASMS IN BONE MARROW TREPHINE BIOPSY
Objectives: To assess the frequency of various grades of fibrosis in chronic myeloproliferative neoplasms in bone marrow trephine biopsy.
Study design: Cross-sectional study.
Place & duration of study: This study was carried out at Pathology Department. Foundation University Medical College, Islamabad from January 2011 to December 2011.
Materials & Methods: One hundred and nine patients of chronic myeloproferative neoplasms were selected by convenience sampling. The histopathological sections were examined for various grades of fibrosis. All the demographic data which included the information pertinent to interpretation and histopathological findings were recorded on Performa. Data were analyzed by using Statistical Package for Social Sciences (SPSS) Window version 17 statistical package. . The results were described as frequency.
Results: The mean age was 50.7 years standard with a deviation of ± 7.4 years. There were 90 (83%) female cases and 19 (17%) male patients. Grade-0 fibrosis was most common (n=45) whereas grade-3 fibrosis was diagnosed with least frequency (n = 11). Grade – 1 (n = 31) and grade – 2 (n = 22) fell in between
Conclusion: By using WHO grading system of marrow fibrosis, the lower grades of fibrosis were most frequently diagnosed grades as compared to the higher grades of fibrosis in the patients of chronic myeloproliferative neoplasms.
Key words: Bone marrow, Fibrosis, Chronic myeloproliferative neoplasms.