Intestinal Lesions of Streptozotocin Diabetes and the Effects of Azadirachta indica Treatment
Abstract
Objective: Streptozotocin (STZ) uptake into cells is mediated by GLUT-2 transporter. Besides pancreatic B cells, this transporter is also expressed by epitheliocytes of the intestinal mucosa, hepatocytes, and cells of renal tubules. In this work, we studied the effects of chronic streptozotocin diabetes on the morphology of ileal epithelium. We also report the effects of chronic Azadirachta indica treatment on STZ-induced ileal lesions.
Material Methods: Twenty-five Wistar rats of both sexes (5-8 weeks old) were used. Diabetes was induced in 15 rats with an i.p. dose of 70 mg/kg bw/d of STZ in citrate buffer (0.1 M; pH 4.5). Animals were randomly sorted into five groups of five rats each: control, diabetic, diabetic + neem, diabetic + glibenclamide, neem only.
Results:Â Azadirachta indica was administered at 500 mg/kg bw/d for 50d. By 50d, diabetic rats showed superficial erosion of ileal mucosa with necrosis of goblet cells. Such lesions were however absent in hyperglycemic and normoglycemic rats treated with neem.
Conclusion: These findings suggest that (i) chronic streptozotocin diabetes is associated with intestinal lesions; (ii) neem prevents STZ-induced intestinal lesions; and (iii) exposure of intestinal mucosa to the leaf extract of Azadirachta indica in non-diabetic rats is not associated with deleterious effects.
Key words: Azadirachta indica, streptozotocin diabetes, intestinal lesionsDownloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2016 Oluwole B Akinola, Ezekeil A Caxton Martins, Ahelaje A Abdulazeez, Luciana Dini
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Readers may “Share-copy and redistribute the material in any medium or format” and “Adapt-remix, transform, and build upon the material”. The readers must give appropriate credit to the source of the material and indicate if changes were made to the material. Readers may not use the material for commercial purpose. The readers may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.