ASSOCIATION OF C– REACTIVE PROTEIN AS AN INFLAMMATORY MARKER WITH THE GLYCAEMIC STATUS OF THE ALLOXAN TREATED DIABETIC RATS

Authors

  • Maujid Masood Malik
  • Abdul Khaliq Naveed
  • Zubair Ahmad Awan
  • Amena Rahim
  • Tehmina Qamar

Abstract

Objectives: To Measure the level of C-reactive protein and see its association with the glycaemic status (fasting blood glucose, glycosylated Hb) of normal and diabetic rats.

Settings:          Animal house / National Reference Laboratory for Poultry Diseases (NRLPD), Animal Division of National Agriculture Research Centre (NARC) Islamabad, Department of Biochemistry & Molecular Biology Army Medical College Rawalpindi.

Study Design:                         Experimental study

Duration:                                 December 2006 to January 2007

Sample Size:                60 Albino rats

Group I (Normal Group):        30 normal.

Group II (Study Group):        30 Diabetic.

 

Methodology: Blood glucose levels were determined by applying glucose oxidase method while determination of total HbA1c was performed by Diagnostic kit. C reactive protein was also measured by the ELISA kit.

Results: Significant difference found in the values of fasting glucose with the p < 0.05, of the normal & diabetic groups but no significant difference was present in the values of Glycosylated Hb (HbA1c) (p > 0.05) of both groups. There was no significant difference in the values of C-reactive protein of the normal & diabetic groups (p > 0.05).

Conclusion: In a rat model of diabetes mellitus, hyperglycaemia of short duration has no role in producing inflammation as is indicated by no rise in the levels of bioinflammatory marker C-reactive protein.

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Published

03-08-2016

How to Cite

1.
Malik MM, Naveed AK, Awan ZA, Rahim A, Qamar T. ASSOCIATION OF C– REACTIVE PROTEIN AS AN INFLAMMATORY MARKER WITH THE GLYCAEMIC STATUS OF THE ALLOXAN TREATED DIABETIC RATS. Pak J Pathol [Internet]. 2016 Aug. 3 [cited 2024 Apr. 20];20(3). Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/248

Issue

Vol. 20 No. 3 (2009)

Section

Articles

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Copyright (c) 2016 Maujid Masood Malik, Abdul Khaliq Naveed, Zubair Ahmad Awan, Amena Rahim, Tehmina Qamar

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