THE EXPRESSION OF ERYTHROPOIETIN AND ERYTHROPOIETIN RECEPTOR IN ORAL SQUAMOUS CELL CARCINOMA

Authors

  • Sajid Hanif
  • Muhammad Noman Sheikh
  • Syed Fareed Mohsin
  • Kefi Iqbal
  • Syed Azhar Ahmed

Abstract

Objective: The objective of this study is to analyse the in vitro expression of Erythropoietin and Erythropoietin Receptor in pathological biopsies of oral squamous cell carcinoma.

Material and Methods: The biopsy samples of oral squamous cell carcinoma provided by Barts and the London NHS trust hospital. The samples were taken from buccal mucosa, lip, lateral border of tongue, tonsilor region, oropharynx and nasal columnella. These samples were cut to form the formalin fixed, paraffin embedded tissue blocks, and immunohistochemistry was performed on each sample, which later on viewed under microscope.

Result: In this study erythropoietin staining was present in all the specimens of oral squamous cell carcinoma studied. Within the tumors Erythropoietin staining showed a differential pattern that was related to the differentiation of the tumour. In poorly differentiated tumours, erythropoietin was present in all the tumour cells spread throughout the tissue. In well differentiated tumours, erythropoietin staining was only present in the prickle cell layer. Erythropoietin receptor staining within the tumours showed a differential staining too. In the poorly differentiated tumours, erythropoietin receptor was only present in the muscle plus adjacent inflammatory cells and was absent in the tumour islands. In the well differentiated tumours some islands showed weak staining in the prickle cell layer, while the surrounding inflammatory infiltrate was positive.

Conclusion: This study has confirmed that oral squamous cell carcinoma express both erythropoietin and erythropoietin receptor. Erythropoietin staining showed a differential pattern that was related to the differentiation of tumour. Erythropoietin receptor was expressed in salivary gland ducts and serous but not in mucous acini. These findings suggest that more studies are needed to explore the functional significance of erythropoietin and erythropoietin receptor in oral squamous cell carcinoma and in salivary glands.

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Published

03-08-2016

How to Cite

1.
Hanif S, Sheikh MN, Mohsin SF, Iqbal K, Ahmed SA. THE EXPRESSION OF ERYTHROPOIETIN AND ERYTHROPOIETIN RECEPTOR IN ORAL SQUAMOUS CELL CARCINOMA. Pak J Pathol [Internet]. 2016 Aug. 3 [cited 2024 Apr. 23];21(2). Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/164

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