Comparison of serum vitamin D and plasma PTH levels between pre and post-menopausal females at tertiary care hospital in Rawalpindi

Authors

  • Amna Khan
  • Amjad Nasim
  • Sami Saeed
  • fghgfh Mehmood Malik

Abstract

Objective: To determine the relationship between increasing age of females and falling levels of vitamin D (25 (OH) D) and PTH.

Materials and Methods: It was a comparative cross sectional study conducted in conformance with good clinicalpractices. It was conducted at Fauji Foundation Hospital Rawalpindi from May 2009 to May 2011.  Females 15 – 35 years of age (group 1) and in all female patients above 50 years of age (group 2) were included. Both groups comprised participants from the lower socioeconomic strata.

Results: In group1, mean age was 22.38 years. Serum 25 (OH) D levels ranged from 4 nmol/L to 250 nmol/L. Plasma PTH levels ranged from 4 pg/ml to 35.4 pg/ml. In group 2, age range of patients was 50 – 86 years and mean age in this group of patients was 60.37 years. Serum 25 (OH) D levels range from 4 nmol/L to 123 nmol/L. Plasma PTH levels ranged from 9.2 pg/ml to 218 pg/ml. By the use of a cutoff of 20 nmol/l, 23% women less than 35 years of age and 42% women above 50 years of age were classified as having a vitamin D deficiency. By the use of a cutoff of 50 nmol/l, 65% women less than 35 years of age and 51% of women above 55 years of age were classified as having a vitamin D insufficiency. Correlation studies between age and 25 (OH) D of both groups showed negative correlation; hence signify that increasing age of patients result in falling 25 (OH) D levels.

Conclusions: Serum 25 (OH) D levels were significantly lower in post-menopausal woman as compared to premenopausal. Plasma PTH levels had a negative correlation with serum 25 (OH) D with increasing age.

Key words: Osteoporosis, 25 hydroxyvitamin D, PTH, Calcium.

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Published

03-08-2016

How to Cite

1.
Khan A, Nasim A, Saeed S, Malik fghgfh M. Comparison of serum vitamin D and plasma PTH levels between pre and post-menopausal females at tertiary care hospital in Rawalpindi. Pak J Pathol [Internet]. 2016 Aug. 3 [cited 2024 Mar. 29];22(3). Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/118

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