Comparison of serum vitamin D and plasma PTH levels between pre and post-menopausal females at tertiary care hospital in Rawalpindi
Abstract
Objective: To determine the relationship between increasing age of females and falling levels of vitamin D (25 (OH) D) and PTH.
Materials and Methods: It was a comparative cross sectional study conducted in conformance with good clinicalpractices. It was conducted at Fauji Foundation Hospital Rawalpindi from May 2009 to May 2011.  Females 15 – 35 years of age (group 1) and in all female patients above 50 years of age (group 2) were included. Both groups comprised participants from the lower socioeconomic strata.
Results: In group1, mean age was 22.38 years. Serum 25 (OH) D levels ranged from 4 nmol/L to 250 nmol/L. Plasma PTH levels ranged from 4 pg/ml to 35.4 pg/ml. In group 2, age range of patients was 50 – 86 years and mean age in this group of patients was 60.37 years. Serum 25 (OH) D levels range from 4 nmol/L to 123 nmol/L. Plasma PTH levels ranged from 9.2 pg/ml to 218 pg/ml. By the use of a cutoff of 20 nmol/l, 23% women less than 35 years of age and 42% women above 50 years of age were classified as having a vitamin D deficiency. By the use of a cutoff of 50 nmol/l, 65% women less than 35 years of age and 51% of women above 55 years of age were classified as having a vitamin D insufficiency. Correlation studies between age and 25 (OH) D of both groups showed negative correlation; hence signify that increasing age of patients result in falling 25 (OH) D levels.
Conclusions: Serum 25 (OH) D levels were significantly lower in post-menopausal woman as compared to premenopausal. Plasma PTH levels had a negative correlation with serum 25 (OH) D with increasing age.
Key words: Osteoporosis, 25 hydroxyvitamin D, PTH, Calcium.
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Copyright (c) 2016 Amna Khan, Amjad Nasim, Sami Saeed, fghgfh Mehmood Malik
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