BRAFV600E mutation in a case of hairy cell leukaemia

Authors

  • Muhammad Arif Sadiq
  • Suhaib Ahmed
  • Farhat Abbas Bhatti
  • Nadir Ali
  • Ghassan Umair Shamshad

Abstract

Hairy cell leukaemia is a clonal B cell lymphoproliferative disorder. Patient usually presents to clinician with cytopenias and splenomegaly. Common symptoms include abdominal discomfort, fatigue, generalized weakness, recurrent infections, bruising and bleeding complaints. We present a case of Hairy cell leukaemia with only 25% neoplastic cells in which BRAFV600E mutation was detected. Cytochemical stain, trephine biopsy and immunophenotyping were also consistent with Hairy cell leukaemia.

Key Words: Hairy cell Leukemia, splenomegaly, flow cytometry

Published

03-08-2016

How to Cite

1.
Sadiq MA, Ahmed S, Bhatti FA, Ali N, Shamshad GU. BRAFV600E mutation in a case of hairy cell leukaemia. Pak J Pathol [Internet]. 2016 Aug. 3 [cited 2024 Apr. 16];22(4). Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/114

Issue

Vol. 22 No. 4 (2011)

Section

Case Report

License

Copyright (c) 2016 Muhammad Arif Sadiq, Suhaib Ahmed, Farhat Abbas Bhatti, Nadir Ali, Ghassan Umair Shamshad

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