REFERENCE INTERVAL OF PLACENTAL GROWTH FACTOR IN NON-PREGNANT AND PREGNANT FEMALES

Authors

  • Asma Afaaq Chughtai Institute of Pathology, Lahore Pakistan
  • Muhammad Dilawar Khan Chughtai Institute of Pathology, Lahore Pakistan
  • Hijab Batool Chughtai Institute of Pathology, Lahore Pakistan
  • Omer Chughtai Chughtai Institute of Pathology, Lahore Pakistan
  • Akhtar Sohail Chughtai Chughtai Institute of Pathology, Lahore Pakistan
  • Shakeel Ashraf Chughtai Institute of Pathology, Lahore Pakistan

DOI:

https://doi.org/10.55629/pakjpathol.v34i4.772

Abstract

Objective: To determine the reference interval of placental growth factor in healthy non-pregnant and pregnant females.

Material and Methods: This cross-sectional study was conducted at Chughtai Institute of Pathology Chemical pathology department from January 2023-May 2023. Reference individuals were selected by purposive, non-probability sampling technique from 130 diseased free non-pregnant and 130 disease free pregnant females. Informed consent was obtained from females of reproductive age group who fulfilled the inclusion criteria. Levels for PGF was measured by a fully automated immunoassay analyser Elecsys system Cobas e601. Data was analyzed by using SPSS21. Kolmogorov-Smirnov test was applied.  P value <0.05 was considered significant. The 2.5th and 97.5th percentiles were calculated at 90% CI by using the formula 0.025x(n+1) at rank number 1 and 0.975x(n+1) at rank number 7.

Results: Reference intervals were calculated by Rank-based method. Data values were arranged and rank numbers were allocated. Reference interval of PGF in non-pregnant and pregnant females were determine on the basis of 2.5th and 97.5th percentiles was 3.8 to 12.7 pg/mL and 46.43 to 1148 pg/mL respectively.

Conclusion: Current study findings add on contribution in comparison between reference interval of PGF in healthy non-pregnant and pregnant females. It will subsequently help the gynaecologist, clinicians, pathologist to interpret the results in order to decrease the feto/maternal complications related to pre-eclampsia. PGF levels can be cost effective by reducing unnecessary hospitalization and investigations in females at minimal risk of pre-eclampsia.

Keywords: Reference interval, Placental growth factor, Pre-eclampsia.

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Published

29-12-2023

How to Cite

1.
Afaaq A, Khan MD, Batool H, Chughtai O, Chughtai AS, Ashraf S. REFERENCE INTERVAL OF PLACENTAL GROWTH FACTOR IN NON-PREGNANT AND PREGNANT FEMALES. Pak J Pathol [Internet]. 2023 Dec. 29 [cited 2024 Dec. 22];34(4):102-8. Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/772

Issue

Vol. 34 No. 4 (2023): PAKISTAN JOURNAL OF PATHOLOGY

Section

Articles

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Copyright (c) 2024 Asma Afaaq, Muhammad Dilawar Khan, Hijab Batool, Omer Chughtai, Akhtar Sohail Chughtai, Shakeel Ashraf

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