REFERENCE RANGE OF NT PRO BNP IN HEALTHY PREGNANT FEMALES

Authors

  • Mariam Saeed Combined Military Hospital, Lahore Pakistan
  • Muhammad Zeeshan Rana Combined Military Hospital, Lahore Pakistan
  • Najeebullah Khan Combined Military Hospital, Lahore Pakistan
  • Hina Anwar Combined Military Hospital, Lahore Pakistan
  • Shakeel Ahmed Combined Military Hospital, Lahore Pakistan

DOI:

https://doi.org/10.55629/pakjpathol.v34i3.769

Abstract

Objective: To define the Reference Range of NT pro-BNP (N-terminal pro–B-type natriuretic peptide) during the first trimester of pregnancy in healthy females.

Material and Methods: This Cross-sectional study was conducted in the Department of Chemical Pathology, Combined Military Hospital, Lahore from September to November 2022. This cross-sectional study focused on the reference range of NT pro-BNP in healthy pregnant females. Sampling of the data was done by using the nonprobability consecutive sampling technique. A maximum number of available participants (365 pregnant females) during the study period were recruited. Descriptive statistics were shown as mean ±SD. For the reference range for NT pro-BNP 2.5th percentiles (lower limit) and 97.5th percentiles (upper limit) were estimated.

Results: A total of 365 pregnant females were included with first trimester pregnancy, having the mean age 28.54±5.18 years. Out of 365 participants, 299 females had BMI <25 whereas 66 were overweight. Forty-One females had Hb level ≤ 10 g/dl and 324 females had HB >10 g/dl. The Platelet count was >150 x 10^9/L in 338 women, and ≤150 x 10^9/L in 26 women. The Median of NT pro-BNP was 56.80 pg/mL in the first trimester. Reference range of NT pro-BNP in pregnant women with BMI <25 was (17.89 – 257.00) pg/mL as compared to (16.88 – 130.63) pg/mL in those with BMI >25.

Conclusion: The Reference range of NT pro-BNP changes in pregnancy as compared to healthy non-pregnant adults, likely due to hemodynamic changes associated with pregnancy. This study has defined a Pregnancy-specific reference range of NT pro-BNP in the first trimester which can help diagnose pregnant women with underlying cardiovascular disease.

Keywords: NT pro-BNP, Reference range, Pregnancy

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Published

21-09-2023