SOX10 EXPRESSION IN SELECTIVE MALIGNANT SALIVARY GLAND TUMORS OF INTERCALATED AND EXCRETORY DUCTAL ORIGIN

Authors

  • Madiha Insha Awan Peshawar Medical and Dental College, Peshawar Pakistan
  • Arooj Khurshid Peshawar Medical and Dental College, Peshawar Pakistan
  • Obaid Akhtar HBS Medical and Dental College, Islamabad Pakistan
  • Sabeen Nasir Peshawar Medical and Dental College, Peshawar Pakistan
  • Sara Ziaullah Peshawar Medical and Dental College, Peshawar Pakistan
  • Nasiha Bashir Peshawar Medical and Dental College, Peshawar Pakistan

DOI:

https://doi.org/10.55629/pakjpathol.v33i2.709

Abstract

Objective: To determine the level of immunohistochemical expression of SOX10 in malignant tumors of salivary gland of intercalated ductal and excretory ductal origin.

Material and Methods: An analytical cross-sectional study was designed. Sample size was 90 and categorised into two groups i.e., intercalated ductal (adenoid cystic carcinoma AdCC and polymorphous low-grade adenocarcinoma PLGA) and excretory ductal (mucoepidermoid carcinoma MEC). Blocks were retrieved from the histopathology lab of Pakistan Institute of Medical Sciences (PIMS), Peshawar Medical College (PMC) and Islamabad Diagnostic Center (IDC) from 2015 – 2020. Hematoxylin & Eosin (H&E) and Immunohistochemistry (IHC) slides were prepared and examined under microscope. Statistical analysis was done using SPSS version 25.

Results: The intensity was found weak in 24 (85.7%) and moderate 4 (14.3%) in excretory ductal tumors. Similarly, the intensity was strong and intense in most of the intercalated ductal tumors compared to none in the excretory ductal tumors. The difference was statistically highly significant (p-value,<0.001). Similarly, the proportion of SOX10 was found with no positive cells in 25 (89.3%) and <10% cells in 3 (10.7%) cases of excretory ductal tumors whereas in the intercalated ductal tumor cases almost two third (62.8%) patients had cells between 51- 80% and above 80%. The difference in proportion of SOX10 was found statistically significant (p-value, <0.001).

Conclusion: The conclusion of this study is that immunohistochemical expression of SOX10 can help in differentiating the origin of tumors of intercalated ductal and excretory ductal origin.

Key Words: Adenoid cystic carcinoma, Polymorphous low-grade adenocarcinoma, Mucoepidermoid carcinoma, SOX1O, Immunohistochemistry, Hematoxylin & eosin.

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Published

30-06-2022