A RARE ASSOCIATION OF ANTI- GABA-B RECEPTOR WITH ANTI HU ANTIBODIES IN AUTOIMMUNE ENCEPHALITIS: A CASE REPORT

Authors

  • Tahira Mohammad Shifa International Hospital, Islamabad Pakistan
  • Muhammad Amjad Shifa International Hospital, Islamabad Pakistan
  • Aftab Akhtar Shifa International Hospital, Islamabad Pakistan
  • Tahir Aziz Ahmed Shifa International Hospital, Islamabad Pakistan

DOI:

https://doi.org/10.55629/pakjpathol.v33i1.702

Abstract

ABSTRACT

Antibodies to the gamma aminobutyric acid-B receptor (Anti-GABA-B-R) encephalitis is an uncommon subtype of autoimmune encephalitis (AE) in which IgG antibodies directed against the B1 subunit of the GABA-B-R has been described. Clinically it presents as limbic encephalitis (LE) which is characterized by seizures, psychosis, and memory loss with progression to autonomic dysfunction, altered consciousness and death. We present a case of an elderly male who presented in the ER due to progressive agitation, confusion, and irritability. Immunological workup revealed anti GABA-B-R antibody and anti Hu. After admission his consciousness rapidly deteriorated over the next few days, and he was intubated. The patient developed septic shock and due to poor prognosis, the patient’s family requested withdrawal of ventilatory support.

Downloads

Published

31-03-2022