HIGH TITRE ANTI-A AND ANTI-B ANTIBODIES IN GROUP ‘O’ BLOOD DONORS - A TERTIARY CARE HOSPITAL BLOOD BANK EXPERIENCE

Authors

  • Anum Sharif Combined Military Hospital (National University of Medical Sciences), Multan Pakistan
  • Mansoor Ishaq Raja Armed Forces Institute of Transfusion (National University of Medical Sciences), Rawalpindi, Pakistan
  • Waqas Hanif Combined Military Hospital (National University of Medical Sciences), Multan Pakistan
  • Muhammad Sajid Yazdani Combined Military Hospital, Abbottabad Pakistan
  • Hamid Iqbal Combined Military Hospital (National University of Medical Sciences), Multan Pakistan
  • Noreen Anwar Combined Military Hospital (National University of Medical Sciences), Multan Pakistan

DOI:

https://doi.org/10.55629/pakjpathol.v33i1.700

Abstract

Objective: To determine the frequency of titre anti-A and anti-B antibodies in donors with blood group O.

Material and Methods: The study was conducted at Combined Military Hospital Multan from October 2019 to April 2020. This cross-sectional study has conducted after the approval of ethics review committee; A total of 300 individuals with blood group O reported for blood donation during the study period were considered in this study. After their consent, 10 ml whole blood of each donor was collected in two tubes, 3 ml collected in Ethylenediaminetetraacetic acid (EDTA) tube and 7 ml in plain tube. Anti-A & anti-B antibodies titers were performed using pooled blood group A and B red cells by tube method at room temperature and 37° C.

Results: Male consisted of 174 (58%) and female consisted of 126 (42%) with male to female ratio of 1.5:1 out of 300 blood donors. The ages of individuals range from 20 to 50 years (32.8 ± 7.2). The frequencies of titer of anti-A antibodies and anti-B antibodies were found to be 17.7% and 9.0% respectively.

Conclusion: Titer of anti-A antibodies is high in considerable number of blood group O donors supports cautious use of Blood group O products in non-O recipients without screening. However, frequency of titer of anti-B antibodies was found to be relatively low.

Key Words: Anti-B, Anti-A, High titre, Blood group O, Non-O Blood group.

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Published

31-03-2022