CLINICOPATHOLOGICAL AND IMMNNOHISTOCHEMICAL PROFILE OF LYMPHOMA OF HEAD AND NECK REGION

Authors

  • Uzma Jabbar Khan University College of Dentistry, University of Lahore, Lahore Pakistan
  • Wajiha Alamgir University College of Dentistry, University of Lahore, Lahore Pakistan
  • Aroosa Ashraf University College of Dentistry, University of Lahore, Lahore Pakistan
  • Adeel Haider University College of Dentistry, University of Lahore, Lahore Pakistan
  • Salman Rashid Avicenna Medical and Dental College, Lahore Pakistan
  • Faheem Abrar 3Punjab Health Care Commission, Lahore Pakistan

Abstract

Objective: The study was intended to analyze the frequency distribution and relative sites of occurrence of extra nodal lymphoma in head and neck region. Moreover, it was also focused to set down the histological types and subtypes of the diagnosed lymphoma through various immunohistochemical panels. The objective of the study is to evaluate the frequency of co-expression of c-Myc and BCL-2 in Diffuse large B-cell lymphoma.

Material and Methods: This cross-sectional observational study was conducted in the department of Oral and Maxillofacial Pathology of University Dental Hospital, University of Lahore, Lahore. Total 39 proven cases of head and neck lymphoma from period of June 2018 to July 2021 were included. Inclusion criteria consist of lymphoma of head and neck region in age group 25years to 100 years. Exclusion criteria comprised of lymphoma in age less than 25 years and lymphoma of CNS. The immunohistochemical panel used included the antibodies against LCA, CD3, CD10, CD15, CD20, CD23, CD40, CD43, CK, Cyclin D1, Bcl2, GCDFP-15, Kappa and Lambda. SPSS version 25 was used to analyze the data. Pearson chi square was applied and p < 0.05 was taken as significant.

Results: Out of 39 cases, 21 (54%) were males and 18 (46%) were females. The mean age was 57.89 +16.43 years. Out of the total, 38 cases were diagnosed as Non-Hodgkin lymphoma (NHL) and only one turned out to be Classical Hodgkin lymphoma of mixed cellularity type. Among NHL diffuse large B cell Lymphoma (DLBCL) was greatest in number (n=29 ,76.31%), followed by 6 cases of marginal zone (15.3%) and one case each of small lymphocytic lymphoma, follicular lymphoma and unspecified peripheral T cell lymphoma. The most common extra nodal site involved was tonsil n=18 (46.5%), followed by parotid gland n=6 (15.38%), palate n=3 (7.69%), alveolar ridge (n=2 ,5.12%), tongue n=2 (2.15%), submandibular region n=2 (5.12%), buccal mucosa n=2 (5.12%), upper jaw n=1 (2.56%), oropharynx n=1 (2.56%), gingiva n=1 (2.56%) and lip n=1 (2.56%)

Conclusion: Non-Hodgkin lymphoma comprise of 97.4% of total cases where as Hodgkin lymphoma only 2.5%. Most common site involved was tonsil with greatest frequency of diffuse large B cell lymphoma.

Key Words: Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Immunohistochemistry, Diffuse Large B cell lymphoma.

Downloads

Published

31-12-2021

How to Cite

1.
Khan UJ, Alamgir W, Ashraf A, Haider A, Rashid S, Abrar F. CLINICOPATHOLOGICAL AND IMMNNOHISTOCHEMICAL PROFILE OF LYMPHOMA OF HEAD AND NECK REGION. Pak J Pathol [Internet]. 2021 Dec. 31 [cited 2024 Dec. 22];32(4):142-6. Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/688

Issue

Vol. 32 No. 4 (2021): Pakistan Journal of Pathology

Section

Articles

License

Copyright (c) 2021 Uzma Jabbar Khan, Wajiha Alamgir, Aroosa Ashraf, Adeel Haider, Salman Rashid, Faheem Abrar

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Readers may “Share-copy and redistribute the material in any medium or format” and “Adapt-remix, transform, and build upon the material”. The readers must give appropriate credit to the source of the material and indicate if changes were made to the material. Readers may not use the material for commercial purpose. The readers may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.