Comparison of lipid profile in chronic hepatitis "C" patients before and after antiviral treatment
Objective: To evaluate the lipid profile: cholesterol, triglycerides (TG), Low density lipoprotein (LDL), High density lipoprotein (HDL) in Chronic HCV infected patients before and after antiviral therapy.
Material and Methods: This study was conducted in Department of Chemical Pathology at King Edward Medica University, Lahore. Fasting blood samples were collected from 84 HCV infected patients before and after 6 months of treatment from Out Patient department (OPD) Mayo Hospital Lahore for lipid profile and were processed at Chemical Pathology Department of KEMU, Lahore. The blood samples were analyzed for lipid profile by standard enzymatic methods.
Results: The study was conducted on 84 patients including 30 males and 54 females with a mean age of 38±10 years. According to Body Mass Index (BMI) only 12 patients were overweight while rest of the patients having normal BMI. We analyzed lipid profile before and after treatment. There was a significant increase in post treatment cholesterol level 179±27mg/dl as compare to pre- treatment 151±19 mg/dl with a P-value <0.001. Mean Triglyceride (TG) levels also increased significantly after treatment 87±18 mg/dl v/s 119±26 mg/dl with a P-value <0.001. Low Density Lipoprotein (LDL) was also increased significantly after treatment 89.8±15.1 mg/dl v/s 112.8±24.1mg/dl with a P-value <0.001. But the mean High-Density Lipoprotein (HDL) was not changed significantly after treatment 43±7mg/dl as compared to before treatment 42±6 mg/dl with a p-value 0.399.
Conclusion: Hepatitis C infection was associated with deranged (lowering) of lipid profile that was rearranged (normal) after the resolution of infection in successfully treated patients. Lipid profile monitoring may help in the prognosis of hepatic infection severity and may also act as a good predictive sign. This may help the clinicians in better counseling and timely anticipation and intervention regarding chronic HCV to decrease the risk of coronary heart disease (CHD) in future.
Key Words: Chronic hepatitis C, Cholesterol, Coronary heart diseases, HDL-c, Lipid profile.