• Syed Muhammad Ishaque Bolan Medical College, Consultant Pathologist Sandeman Civil (Prov;) Hospital Quetta Pakistan
  • Shaista Gul Bolan Medical College Quetta Pakistan
  • Abdullah Jan Loralai Medical College, Loralai Pakistan
  • Shahnaz Imdad Kehar Jinnah Postgraduate Medical Center (JPMC), Karachi Pakistan
  • Sanaullah Gazozai Bolan Medical College, Quetta Pakistan
  • Nazish Jaffer Sindh Medical College, Jinnah Sindh University of Medical and Health Science Karachi Pakistan


Objective: To study the histological grades of papillary urothelial carcinoma in various age groups and gender.

Material & Methods: This cross-sectional study was conducted in the department of pathology BMSI, JPMC Karachi from Jan 2009 to Dec 2016. Total numbers of 247 cases of urothelial carcinoma were reviewed and morphological diagnosis done on H&E. Histological grades of papillary urothelial carcinoma were categorized, the data analyzed by SPSS version 21 and excel 2007 version.

Results: In total 247 cases, 41% cases were high grade, 38% were low grade and 21% were invasive variant of papillary urothelial carcinoma. In male gender 90%, 85% & 77% cases were noted in high, low grade and invasive PUC, while in female sex 23%, 15% &10% cases were in invasive, low and high grade respectively. Majority of the lesion were seen in 5th & 6th decades i-e 59% cases as compare to other age groups and only 02% cases was seen in less than 30 years of age and mean & median age was 57.62 & 65 years for this carcinoma.

Conclusion: Out of 247 cases, 101, 93 & 53 cases were high grade, low grade and invasive variants of papillary urothelial carcinoma. Majority were noted in high grade, followed by low grade and invasive type of PUC. Gender wise were in high grade 91, 10, in low grade 79, 14 and in invasive PUC 41, 12 cases were noted in male and female sex respectively. While 85, 60, 57, 24, 17 & 04 cases were in 5th, 6th, 4th, more than 7th, 3rd and less than 3rd decades respectively, minimum and maximum age was 22 and 90 years noted.

Key Words: Age, Gender, Histological grades, Papillary urothelial carcinoma (PUC), Transurethral resection of bladder tumor (TURBT), World health organization (WHO).