HAEMATOLOGICAL PARAMETERS IN COVID-19 INFECTION WITH EMPHASIS ON NEUTROPHIL-LYMPHOCYTE RATIO (NLR) AND PLATELET-LYMPHOCYTE RATIO (PLR)
Objective: The objective of our study was to assess and evaluate the various hematological parameters including the alterations in new CBC parameters like Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) in patients with laboratory confirmed COVID-19.
Material and Methods: A single-centre tertiary care hospital-based cross-sectional prospective study was conducted at Pathology Department, Pakistan Institute of Medical Sciences (P.I.M.S), Islamabad. Haematological profiles of one hundred and fifteen hospitalized, moderate to severely affected cases of COVID-19 confirmed on Polymerase Chain Reaction of nasopharyngeal and oropharyngeal swabs were included in the study.
Results: This study included 115 patients with SARS-CoV2 confirmed on RT-PCR on respiratory specimens over a 3-month period, and several haematological abnormalities were studied. Neutrophilia was seen in 52 (45.2%) patients, lymphopenia was observed in 50 (43.5%) patients. New CBC parameters, NLR and PLR were evaluated and found as raised in our cases, 10.08 ± 12.63 and 283.0 ± 310.07 respectively. Out of 115 positive cases enrolled in our study, 89(77%) patients had normal platelet counts, 11(9.5%) patients had mild thrombocytopenia. Hemoglobin and mean red cell indices were within normal limits. The mean PT was 16.63±7.11 sec, and mean APTT was 39.69 ± 13.58 sec.
Conclusion: COVID-19 is accompanied with a wide-ranging array of haematology-related abnormalities; neutrophilia, lymphopenia along with increased NLR and PLR were noted in our study.
Key Words: SARS-CoV2, COVID-19, Lymphopenia, Neutrophil-lymphocyte ratio, Platelet-lymphocyte ratio.