CDX2 expression: Development of lower esophageal adenocarcinoma

Authors

  • Humera Jabeen Peshawar Medical College, Peshawar
  • Lubna Avesi Dow International Medical College, Dow University of Health Sciences, Karachi Pakistan
  • Saba Hassan Shamim Dow International Medical College, Dow University of Health Sciences, Karachi Pakistan
  • Farheen Danish Dow International Medical College, Dow University of Health Sciences, Karachi Pakistan
  • Nazia Qamar Fazaia Ruth Pfau Medical College, Karachi Pakistan
  • Maryam Moula Bakhsh` Dow Institute of Technology, Dow University of Health Sciences, Pakistan

Abstract

Objectives: To look into the expression of CDX2 in normal and various abnormal esophageal epithelial conditions in human subjects.

Material and Methods: This study was conducted at Department of Pathology, Dow University of Health Sciences and Al-Tibri Medical College, Karachi. After ERC (ethical review committee) approval 88 human subjects were selected through non-probability sampling using inclusion and exclusion criteria 22 subjects as control (group-I) and 22 individuals with Barrett esophagus (Group-II), 22 patients with dysplasia (Group-III) and 22 known patients of esophageal adenocarcinoma (Group-IV). Demographic data were collected on proforma while histopathological changes and biomarkers were evaluated by the department of pathology, Chi-square was the statistical techniques used.

Results: There were 70 (79.55%) males and 18 (21.45%) females. The mean age was 43.09±6.52 years in group-I while 56.63±2.64 years in group-II and 61.68±4.23 years in group-III whereas it was 63.90±3.80 years in group IV. CDX-2 was found expressed in 36(40.91%) patients where as it was negative in 52 (59.09%) patients.

Conclusion: There is significant association in CDX2 expression in various epithelial abnormalities of the esophagus from Barrett esophagus to esophageal adenocarcinoma.   

Key Words: CDX2, Dysplasia, Adenocarcinoma.

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Published

31-12-2020

How to Cite

1.
Jabeen H, Avesi L, Shamim SH, Danish F, Qamar N, Bakhsh` MM. CDX2 expression: Development of lower esophageal adenocarcinoma. Pak J Pathol [Internet]. 2020 Dec. 31 [cited 2024 Dec. 22];31(4):111-3. Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/579

Issue

Vol. 31 No. 4 (2020): Pakistan Journal of Pathology

Section

Articles

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Copyright (c) 2020 Humera Jabeen, Lubna Avesi, Saba Hassan Shamim, Farheen Danish, Nazia Qamar, Maryam Moula Bakhsh`

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