FREQUENCY OF MALE ENDOCRINE DISORDERS IN DIFFERENT SPERM ABNORMALITIES IN PAKISTANI POPULATION
Objective: To determine the frequency of endocrine disorders in Pakistani male.
Material and Methods: It was cross sectional study carried out at Armed Forces Institute of Pathology, Rawalpindi from Jan 2018 to Jan 2019. Blood and semen were taken by simple random sampling from 131 selected infertile male populations. Hormonal analysis was done on ADVIA Centaur XP by chemiluminence and semen morphology analysis on microscope. After analysis data was analyzed by Statistical Package of Social Science SPSS v.21.
Results: Among 131 infertile male’s participants, mean aged was 31.60 ±5.93 years. Semen morphological analysis showed 32 (24.4%) normal profile and 99 (75.5%) abnormal morphology. Abnormal sperms morphology showed frequencies of azoospermia 45 (34.4%), asthenzoospermia 26 (19.8%), oligospermia 4 (3.1%) and oligoasthenzoospermia 24 (18.3%). Azoospermic precipitants group (n=45) had 24 (53.3%) normal endocrine fertility profile, 3 (6.7%) secondary hypogonadism, 17 (37.7%) primary hypogonadism and 1(2.2%) having hyperprolactinaemia. Hormonal profile parameters of azoospermic group participants were compared with individuals having normal semen analysis by independent t test which showed statistically significant difference in LH (p-value =0.015) and FSH (p-value=0.001) and non-significant difference for age (p-value =0.885), Testosterone (p-value =0.240) and prolactin (p-value =0.854).
Conclusion: Primary hypogonadism (testicular failure) with azoospermia was the frequently occurring cause of infertility in Pakistan male population.
Key Words: Endocrinopathies, Hyper gonadotropic hypogonadism, Infertility, Follicle stimulating hormone, Luteinizing hormone.