Biochemical prevalence of polycystic ovarian diseases, premature ovarian failure and thyroid dysfunction in women of Rawalpindi cohort
Objective: To determines the frequency of polycystic ovarian diseases, premature ovarian failure and thyroid dysfunction on the basis of biochemical testing in adult Pakistani women.
Material and Methods: It was cross-sectional study carried out at Endocrinology Department, AFIP, Rawalpindi from July2018 to July 2019. A total of 468 non-pregnant women of reproductive age (16-42years) were studied. The data was collected on an approved proforma including presenting and menarche age, menstrual irregularity, acne, pallor, hirsutism, infertility, blood pressure, depressive symptoms and obesity. Blood samples were collected by simple random sampling technique in gel tube. Using the chemiluminence immunoassay methods, FSH, LH on day-2 of menstrual cycle, progesterone, testosterone, prolactin, T3, T4, TSH, SHBG were analyze on ADVIA Centaur. Free androgen index and LH/FSH ratio was calculated manually. For the statistical analysis SPSS 22 was used.
Results: Mean presenting and menarche aged were 28.45 ± 7.24 and 12.40 ± 5.21 years respectively. Clinical findings showed hirsutism (30%), menstrual irregularity (43%), acne (19.6%), obesity >26 kg/m2 (89%), depression (27.9%), infertility (12.8%) and blood pressure >130/90 mmHg was 12.8%. Frequencies of polycystic ovarian syndrome was (25.9%), hyperprolactinemia (23.5%) overt hypothyroidism (16%) and premature ovarian failure (7.4%) on the basis of hormonal assays.
Conclusion: Polycystic ovarian syndrome is most frequently occurring endo-crinopathies in Pakistani adult women.
Key Words: Follicular Stimulating Hormone (FSH), Luteinizing Hormone (LH), Polycystic ovarian syndrome (PCOS).