A RETROSPECTIVE STUDY ON VARIOUS CLINICO-RADIOLOGICAL AND PATHOLOGICAL DIAGNOSIS FOR TUBERCULOUS MENINGITIS AMONG AFGHANI IMMIGRANTS

  • Fahad Hassan Shah Centre of Biotechnology and Microbiology, University of Peshawar, Pakistan
  • Abid Ali Khan Muhammad College of Medicine, Peshawar, Pakistan
  • Saeed Ahmad Centre of Biotechnology and Microbiology, University of Peshawar, Pakistan
  • Syed Turab Ali Shah Centre of Biotechnology and Microbiology, University of Peshawar, Pakistan
  • Jamshaid Ahmad Centre of Biotechnology and Microbiology, University of Peshawar, Pakistan
  • Sadia Khan Centre of Biotechnology and Microbiology, University of Peshawar, Pakistan
  • Saad Salman Department of Pharmacy, the University of Lahore, (Islamabad Campus), Pakistan

Abstract

Objective: The manifolds of mycobacterium is very enigmatic and can only be ruled out through clinical experience. To understand these variables, an extensive study of clinico-radiology, pathological aspects, and comorbidity is critical. The purpose of the present study is to encompass various clinical, imaging, microbiological, and radiological parameters for rapid differential diagnosis for tuberculous meningitis.

Material and Methods: This retrospective case series study was carried out in Lady Reading Hospital from 2014-2016, and a total of 90 Afghani patients were studied for their clinical presentation, radiological records, and pathology lab results along with underlying co-morbid conditions

Results: Our results showed that, among these 90 patients, Female patients (24, 26.7%) were outnumbered by male patients 66 (73.3%), and Convulsion (3, 3.33%) was least presenting symptom as compared to Fever (78, 86 %.).  A majority had complications in their cranial nerves (60, 66.7%), whereas few had in hypoglossal nerves (1, 1.1%). Imaging studies revealed intense hydrocephalus that was more common in males (27, 30%) than female patients (10, 11.11%).

Conclusions: Clinical parameters (Fever, Headache, and Meningeal stiffness), Imaging considerations (Cranial and Abducens nerve palsy, Hydrocephalus, and cerebral infarction) and Pathological factors (↑CSF Glucose and ↓ CSF Protein, elevated WBC count in blood and CSF) are potential diagnostic indicators for tuberculous meningitis infection among these Afghani immigrants.

Key Words: Tuberculous Meningitis, Clinico-radiological, Comorbidity, Afghani immigrants

Published
2020-04-01