RETROSPECTIVE ANALYSIS OF DENGUE VIRUS INFECTION: A FOUR-YEAR STUDY

Authors

  • Humaira Aziz Sawal Armed Forces Institute of Pathology (National University of Medical Sciences), Rawalpindi Pakistan
  • Misbah Noor Armed Forces Institute of Pathology (National University of Medical Sciences), Rawalpindi Pakistan
  • Saifullah Khan Niazi Armed Forces Institute of Pathology (National University of Medical Sciences), Rawalpindi Pakistan
  • Eijaz Ghani Armed Forces Institute of Pathology (National University of Medical Sciences), Rawalpindi Pakistan
  • Sumaira Mubarik Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan, Hubei, China
  • Noman Shakoor Armed Forces Institute of Pathology (National University of Medical Sciences), Rawalpindi Pakistan

Abstract

Objective: To conduct retrospective surveillance study of dengue virus infection in patients presenting with febrile illness during 2015-2018.

Material and Methods: Dengue virus NS1 antigen and IgM antibodies were tested by ELISA method in serum samples of patients with febrile illness. Descriptive and analytical measures were used to assess the association of NS1 antigen and IgM antibodies with different risk factors like gender, age and month of the year.

Results: Over the period of four years (2015-2018), 2203 samples were received for dengue NS1 antigen. Out of these, 506 (23%) were positive and 1697 (77%) were negative. Among the positive samples, 162 (32%) were females and 344 (68%) were males, with significant association between NS1 antigen and gender (p<0.05). Similarly, 2089 samples were received for dengue IgM antibodies. Out of these, 389 (19%) were positive and 1700 (81%) were negative. Among positive samples, 128 (33%) were females and 261 (67%) were males (p<0.05). Moreover, significant association was observed for both NS1 and IgM cases with age. In addition, maximum number of positive patients for both NS1 and IgM were between 21-40 years of age. Most of the positive cases were detected during the months of July to October (p<0.05).

Conclusion: Dengue virus infection is a common cause of febrile illness in endemic countries like Pakistan. Male preponderance as well as high number of cases during rainy season were seen. Dengue infection was more prevalent among young people (21-40 years).

Key Words: Dengue, NS1, IgM.

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Published

12-12-2019

How to Cite

1.
Sawal HA, Noor M, Niazi SK, Ghani E, Mubarik S, Shakoor N. RETROSPECTIVE ANALYSIS OF DENGUE VIRUS INFECTION: A FOUR-YEAR STUDY. Pak J Pathol [Internet]. 2019 Dec. 12 [cited 2024 Dec. 22];30(4):97-100. Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/535

Issue

Vol. 30 No. 4 (2019): Pakistan Journal of Pathology

Section

Articles

License

Copyright (c) 2019 Humaira Aziz Sawal, Misbah Noor, Saifullah Khan Niazi, Eijaz Ghani, Sumaira Mubarik, Noman Shakoor

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