THERAPEUTIC EFFECTS OF ZINC SULPHATE IN REDUCTION OF NEONATAL HYPERBILIRUBINEMIA: AN EXPERIMENTAL STUDY

  • Ayesha Waheed Pakistan Institute of Medical Sciences, Islamabad Pakistan
  • Iqtada Haider Shirazi Pakistan Institute of Medical Sciences, Islamabad Pakistan
  • Asma Mustafa Pakistan Institute of Medical Sciences, Islamabad Pakistan
  • Yasir Waheed Pakistan Institute of Medical Sciences, Islamabad Pakistan

Abstract

Objective: Neonatal hyperbilirubinemia is a common condition affecting 60% of the term and 80% of the preterm neonates. Bilirubin can be neurotoxic, when its concentration rises more than 20mg/dl which occurs in 2% of infants. The most prevalent therapeutic method for managing infantile icterus and preventing its complications is phototherapy and exchange transfusions at higher bilirubin levels.

Material and Methods: A quasi experimental study was conducted on 60 neonates with hyperbilirubinemia. They were randomly divided into two groups. Group A (n=30) received zinc sulphate 5mg twice daily for 5 days, in addition to phototherapy. Group B (n=30) received phototherapy. Total serum bilirubin was calculated at 0, 24 and 72 hours for both groups.

Results: No significant difference was found in total serum bilirubin at 0, 24 and 72 hours in both groups (p=0.46, 0.39 and 0.20 respectively)

Conclusion: Oral zinc sulphate is not effective in the treatment of hyperbilirubinemia in neonates.

Key Words: Jaundice, Hyperbilirubinemia, Zinc sulphate, Phototherapy, Physiological Jaundice, Neonate

Published
2019-08-23