SERUM HDL CHOLESTEROL LEVELS IN ADULT HYPERLIPIDEMIC PATIENTS BEFORE AND AFTER TREATMENT WITH NIACIN IN COMBINATION WITH STATIN
Objective: Comparison of different treatment strategies on serum high density lipoprotein levels in adult hyperlipidemic patients.
Study Design: Randomized control trial
Place & Duration of Study: Department of Biochemistry and Department of Chemical Pathology, Sheikh Khalifa Bin Zayed Medical Complex, Lahore. (Jan 2014-15).
Materials and Methods: Hyperlipidemic patients were selected for this study (n=44) and all study cases were equally distributed into two groups “A” and “B”. Different treatment was given to each group. Group A was given only oral statin drug and group B was given statin drug along with niacin. The effect of different drugs on high density lipoprotein (HDL) level of patients was seen on both groups by taking blood sample before commencement of therapy and 12 weeks after treatment.
Results: HDL levels did not vary in group A before and after the treatment but on the other hand group B taking the combination therapy had significantly higher levels of HDL twelve weeks after therapy. The difference between HDL levels in both groups was insignificant before starting therapy. However, this difference became significant after 12weeks of therapy. In our study HDL level decreased in group A but increased in group B after therapy.
Conclusion: ‘Niacin along with stain gives far better results in raising HDL as compared to statin alone.
Key Words: Niacin, Statin, High density lipoproteins, Hyperlipidemia, Cardiovascular events.