PROTECTIVE EFFECT OF SOYABEAN OIL ON ALVEOLAR SEPTAL THICKNESS INDUCED BY BISPHENOL A

Authors

  • Sadia Shaukat Army Medical College (National University of Medical Sciences), Rawalpindi, Pakistan
  • Shabnam Hamid Army Medical College (National University of Medical Sciences), Rawalpindi, Pakistan
  • Aiza Saadia Army Medical College (National University of Medical Sciences), Rawalpindi, Pakistan

Abstract

Objective: To assess the protective effect of soyabean oil on alveolar septal thickness induced by Bisphenol A in alveoli of adult mice.

Study design: Laboratory based randomized control trial.

Place & duration of study: This study was conducted at Department of Anatomy, Army Medical College Rawalpindi in collaboration with National Institute of Health (NIH) Islamabad from November 2015 to June 2016.

Materials and Methods: Forty male and female BALB/c mice were chosen and divided into four groups, each with 10 animals. Group A served as control. Group B was given BPA at a dose of 50milligram/kilogram body weight/day. Group C was treated with soyabean oil at a dose of 500 milligram/day. Group D received BPA at a dose of 50milligram/kilogram body weight/day and soyabean oil at a dose of 500milligram/day. All treatments were given once daily for a period of 8 weeks. Animals were dissected 24hrs after the last dose. Lung tissue processing and H&E staining was done for routine histological study. Alveolar septal thickness was morphometrically and statistically analysed.

Results: Alveolar septal thickness was significantly increased (>3 times normal) in group B in comparison to groups A, C and D and slightly increased in group D in comparison to groups A, B and C.

Conclusion: BPA increases the alveolar septal wall thickness in lungs of adult mice but subsequent administration of soyabean oil protects against thickening of septa. 

Keywords: Bisphenol A, Alveolar septal thickness, Soyabean oil

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Published

29-12-2016

How to Cite

1.
Shaukat S, Hamid S, Saadia A. PROTECTIVE EFFECT OF SOYABEAN OIL ON ALVEOLAR SEPTAL THICKNESS INDUCED BY BISPHENOL A. Pak J Pathol [Internet]. 2016 Dec. 29 [cited 2025 Mar. 12];27(3). Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/362

Issue

Vol. 27 No. 3 (2016)

Section

Articles

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Copyright (c) 2016 Sadia Shaukat, Shabnam Hamid, Aiza Saadia

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