ASSESSMENT OF SERUM LEPTIN LEVELS IN DIFFERENT CATEGORIES OF BODY MASS INDEX

Authors

  • Ahsan Kazmi Al Nafees Medical College, Isra, University, Islamabad, Pakistan
  • Rizwan Hashim Fazaia Medical College, Air University, Islamabad, Pakistan
  • Abdus Sattar CMH Medical College, Lahore, Pakistan
  • Farooq Ahmad Khan Rai Medical College, Sargodha, Pakistan

Abstract

Objective: To assess leptin concentrations in different categories of Body Mass Index (BMI) in a sample of local population of Rawalpindi, Pakistan.

Study design: Observational study.

Place & Duration of Study: Armed Forces Institute of Pathology and Benazir Bhutto Shaheed Hospital, Rawalpindi, 2009-2010 (8 months).

Materials and Methods: Fasting serum leptin concentrations were measured in 100 healthy obese, overweight and non-obese individuals aged 20-50 years, including both sexes. ELISA test was done for serum leptin assay. For each statistical analysis SPSS version 15 was used. The mean, standard deviation, ranges p-values and r-values.

 were calculated for statistical inference

Results: Serum leptin concentrations were strongly associated with sex and the body mass index. Serum leptin level was found comparatively higher in women, in same category of BMI, (mean-64.4 ng/ml, obese group) than in men (mean-40.4 ng/ml, obese group). The mean serum leptin concentration in non-obese women was (12.7 ng/mL) and in men (6.4 ng/mL). Body mass index was strongly positively correlated with serum leptin concentration (r=0.874, P<0.001) in obese group. Serum leptin concentrations were higher in obese individuals (mean 52.8  24.6 ng/mL, P value <0.001) than in non-obese individuals (mean 12.7  6.1 ng/mL). As the grade of obesity increased so does serum leptin levels. It was higher in overweight males (32.6) females (37.8), grade I males (40.4), females (64.4) obesity.

Conclusion: In this sample of the local population, serum leptin concentrations correlated positively in different categories of BMI in both sexes.

Key words: Leptin, Population, Obese, Overweight, Non-obese, Grades of body mass index.

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Published

29-12-2016

How to Cite

1.
Kazmi A, Hashim R, Sattar A, Khan FA. ASSESSMENT OF SERUM LEPTIN LEVELS IN DIFFERENT CATEGORIES OF BODY MASS INDEX. Pak J Pathol [Internet]. 2016 Dec. 29 [cited 2025 Mar. 12];27(3). Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/359

Issue

Vol. 27 No. 3 (2016)

Section

Articles

License

Copyright (c) 2016 Ahsan Kazmi, Rizwan Hashim, Abdus Sattar, Farooq Ahmad Khan

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