EVALUATION OF THE DIAGNOSTIC ACCURACY OF SEROLOGY TEST KIT FOR DETECTION OF H.PYLORI INFECTION IN PATIENTS PRESENTING WITH NONULCER DYSPEPSIA TAKING HISTOPATHOLOGY AS GOLD STANDARD

Authors

  • Gohar Ali Khan
  • Shahila Jaleel
  • Sarah Riaz
  • Bilquis A Suleman

Abstract

Objective: To evaluate the diagnostic accuracy, specificity, sensitivity, positive predictive value and negative predictive value of serological testing in detection of H. pylori infection taking histopathology as gold standard.

Material & Methods: This study was a cross sectional survey carried out at the Histopathology department of Shaikh Zayed Federal Postgraduate Medical Institute Lahore from 27th December 2005 to 23rd November2006.A total of 100 adult patients of both genders with complaints of non-ulcer dyspepsia from whom gastric biopsies were taken by endoscopy in the Gastroenterology Department were included in the study. Two tests namely, histopathological identification of H. pylori (gold standard) and serological test were carried out on each patient. The diagnostic accuracy, specificity, sensitivity, positive predictive value and negative predictive value of serological test were calculated.

Results: The diagnostic accuracy of serological testing in detection of H. pylori infection was 62% in the present study. The sensitivity was 88.6% and Specificity was 41.07 %. Positive predictive value & negative predictive value was 54.16% & 82.1% respectively.

Conclusion: This test is useful for detecting a newly infected patient, but it is not a good test for follow up of treated patients because the results do not indicate if this is a recent infection with H. pylori or otherwise.

Key Words: Helicobacter pylori, Serological test, Diagnosis.

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Published

03-08-2016

How to Cite

1.
Khan GA, Jaleel S, Riaz S, Suleman BA. EVALUATION OF THE DIAGNOSTIC ACCURACY OF SEROLOGY TEST KIT FOR DETECTION OF H.PYLORI INFECTION IN PATIENTS PRESENTING WITH NONULCER DYSPEPSIA TAKING HISTOPATHOLOGY AS GOLD STANDARD. Pak J Pathol [Internet]. 2016 Aug. 3 [cited 2024 Jul. 22];21(2). Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/165

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