Relationship of alloantibody detection with number of blood transfusions

Authors

  • Mohammad Riazuddin Ghori
  • Ehsan Gul Khattak
  • Muhammad Idrees
  • Muhammad Waqas

Abstract

Objectives: To study the presence of the alloantibodies and their relationship with the number of transfusions.

Material and Methods: Two hundred subjects undergoing regular blood transfusions with at least 5 pints of blood within last six months were included in the study.

Results: Out of 200 patients, 140 (70%) were transfusion dependent thalassaemics, 20 (10%) were haemophilics receiving multiple transfusions, 20 (10%) patients were of aplastic anaemia and 20 (10%) patients were with chronic renal failure undergoing haemodialysis.  Antibodies were detected in 9/200 (4.5%) subjects.  Ninety four patients received 5-50 transfusions, 2.13% developed alloantibodies. Sixty five patients received >50-100 blood transfusions, 6.15% developed alloantibodies. Forty one patients received >100 blood transfusions, 7.31% developed alloantibodies.

Conclusion: Frequency of red cell alloantibodies in our transfusion dependent patient population is 4.5%. The risk of developing alloantibodies increased with increasing number of blood transfusions irrespective of underlying disorder.

Keywords: Alloantibody, Indirect antiglobulin test, Blood transfusion.

 

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Published

03-08-2016

How to Cite

1.
Ghori MR, Khattak EG, Idrees M, Waqas M. Relationship of alloantibody detection with number of blood transfusions. Pak J Pathol [Internet]. 2016 Aug. 3 [cited 2024 Dec. 22];23(1). Available from: https://pakjpath.com/index.php/Pak-J-Pathol/article/view/101

Issue

Vol. 23 No. 1 (2012)

Section

Articles

License

Copyright (c) 2016 Mohammad Riazuddin Ghori, Ehsan Gul Khattak, Muhammad Idrees, Muhammad Waqas

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