ANTI-M ANTIBODY IN A NULLIPAROUS NEVER TRANSFUSED WOMAN – A CASE REPORT
Rozina Ghani
Armed Forces Institute of Transfusion, Rawalpindi, Pakistan
Maqbool Alam
Armed Forces Institute of Transfusion, Rawalpindi, Pakistan
Muhammad Sajid Yazdani
Armed Forces Institute of Transfusion, Rawalpindi, Pakistan
Muhammad Ali Rathore
Armed Forces Institute of Transfusion, Rawalpindi, Pakistan
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Pakistan Journal of Pathology (Pak J Pathol)

 

 

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Abstract

Anti-M antibodies are mostly IgM, less commonly mixture of IgM and IgG and rarely solely of IgG type. The naturally occurring Anti-M is usually inactive at 37°C making it insignificant clinically. In less common cases the antibody is active at 37°C making it clinically significant due to its ability to cause haemolytic transfusion reactions (HTR) and haemolytic disease of fetus and newborn (HDFN). We report a case of naturally occurring Anti-M antibody active at 22°C and 37°C as well, detected incidentally in a nulliparous never transfused woman. This clinically significant antibody caused discrepancy in blood grouping also. M antigen negative red cells are required for transfusion in such cases and its presence creates a potential risk of HDFN in future pregnancies.

Keywords: Anti-M antibody, Red cell alloantibody, Naturally occurring anti-M.

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