PATTERN OF CYSTIC FIBROSIS BASED ON SWEAT CHLORIDE TEST IN CHILDREN–A HOSPITAL BASED ANALYSIS

Saima Saima Bashir, Safia Fatima, Munir Akmal Lodhi, Naveed Asif, Ayesha Hafeez, Ammara Ayub, Aamir Ijaz

Abstract


Objective: To determine the clinical and biochemical pattern of cystic fibrosis based on sweat chloride test in children referred with suspected clinical features.

Study design: Cross Sectional Study.

Place & duration of study: Department of Chemical Pathology & Endocrinology, Armed Forces Institute of Pathology (AFIP) Rawalpindi, from Jan 2012 to July 2016.

Results: In the period from Jan 2012 to July we tested 657 patients with 66 % males and 34 % females. Out of 657 patients 22 (3.3%) were confirmed for cystic fibrosis (> 80 mmol/L); 19 (3%) were having borderline values (60 – 80 mmol/L) and 616 were normal. Most common presentation was repeated hospital admissions due to cough and fever 86%. The average amount of chloride in sweat of female patients was 108.6 ± 26.4 mmol/L while for male patients it was 109.1 ± 20.6 mmol/L, p=0.61.

Conclusion: This hospital-based study indicates cystic fibrosis and its variant, although rare, do exist in our set up. So, facilities for sweat chloride and genetic analysis of cystic fibrosis should be increased.

Key Words: Cystic fibrosis, Sweat chloride analysis

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