EFFECT OF AROMATASE INHIBITORS ON EARLY STAGE BREAST CANCER AND FREQUENCY OF JOINT PAIN SYMPTOMS IN POSTMENOPAUSAL WOMEN

Sadia Ikhlaque Sheikh, Fauzia Imtiaz, Shabnum Hasan, Zia Ikramuddin

Abstract


Objective: To find out the effect use of aromatase inhibitors on early stage breast cancer and the frequency of joint symptoms they developed.

Methods: This was a cross-sectional study on postmenopausal breast cancer women, who were receiving the different therapy for cancer. A questionnaire was used, comprises of demographic information and questions related to drug history and joint pain symptoms, and assessing the presence of joint symptoms at initial stage of cancer.

Results: Among 200 patients of this study, 93 (46.5%) reported having aromatase inhibitor-related joint pain and 89 (44.5%) with joint stiffness. Patients who received other medicines have less joint pain and stiffness (odds ratio [OR] _ 4.08, 95% CI, 1.20 to 10.43 and OR _ 4.46; 95% CI, 1.74 to 11.56, respectively).

Conclusion: Present study concluded that symptoms produced by aromatase inhibitor are more frequent in the female patients of breast cancer.

Keywords: Breast cancer, Aromatase inhibitor, Joint Symptoms, Postmenopausal women


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