CLINICOPATHOLOGICAL & IMMUNOHISTOCHEMICAL CHARACTERISTICS OF GASTROINTESTINAL STROMAL TUMORS OF STOMACH IN RESECTION SPECIMENS

Authors

  • Madiha Rehman
  • Saeed Afzal
  • Iqbal Muhammad
  • Shoaib Naiyar Hashmi
  • Syed Naeem Raza Hamdani
  • Muhammad Zeeshan Khan

Abstract

Objective: To determine the clinicopathological, immunohistochemical and prognostic characteristics of gastrointestinal stromal tumors of stomach.

Study design: Descriptive, cross sectional study.

Place & duration of study: Histopathology department, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan from January 2012 to April 2016.

Materials and Methods: Fifty cases of Gastrointestinal stromal tumors of stomach diagnosed on combined H & E and immunohistochemistry were included in this study. Patient’s gender and age were noted. Immunohistochemistry for CD 117, DOG 1, SMA and Ki67 was applied and the results were recorded. The data was analyzed by using computer software program SPSS version 20.

Results: Out of 50 patients of gastrointestinal stromal tumor, the male to female ratio was 1.3:1. The age of the patients ranged between 30 to 80 years with an average age of 49±9.63 years. Average diameter of tumor was 7.8 cm. On histological examination, spindle cell pattern was observed in 84% of cases. Most of the cases (96%) showed positivity for both CD117 and DOG-1 whereas only 4% of cases which were CD 117 negative showed positivity for DOG 1. SMA positivity was seen only in 40% of cases. Based on mitotic rate and Ki 67 index, highest number of cases was seen in Group 3 followed by Group 6. Whereas few cases were seen in Group I, Group 2 and Group 4 risk stratification.

Conclusion: The clinicopathological and immunohistochemical results in our study on stomach GIST are comparable to both local and international studies. Synchronized evaluation of pathological and immunohistochemical features not only establish the prognosis at the time of diagnosis but they also carry therapeutic implication where targeted therapies are being offered.

Key words: CD 117 (c- kit), DOG 1 (Discovered on GIST 1), GIST (Gastrointestinal stromal tumor), H&E (Hematoxylin and Eosin), SMA (Smooth muscle actin).

Author Biography

Madiha Rehman

Dr Madiha Rehman, House No D-626, Wahdat Colony, Taxila Cantt, Taxila, Pakistan 

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Published

25-10-2016

How to Cite

1.
Rehman M, Afzal S, Muhammad I, Hashmi SN, Hamdani SNR, Khan MZ. CLINICOPATHOLOGICAL & IMMUNOHISTOCHEMICAL CHARACTERISTICS OF GASTROINTESTINAL STROMAL TUMORS OF STOMACH IN RESECTION SPECIMENS. Pak J Pathol [Internet]. 2016 Oct. 25 [cited 2024 Mar. 28];27(2). Available from: http://pakjpath.com/index.php/Pak-J-Pathol/article/view/349

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