MORPHOLOGICAL SPECTRUM OF CHRONIC HEPATITIS “C” INFECTION: EXPERIENCE AT FOUNDATION UNIVERSITY MEDICAL COLLEGE AND FAUJI FOUNDATION HOSPITAL RAWALPINDI

Authors

  • Faiza Kazi
  • Mumtaz Ahmad
  • Masood Ahmad Khan
  • Muhammad Luqman

Abstract

Objective: To determine the morphological patterns of HCV related liver disease in our set up

Design: A cross sectional, descriptive study

Place & duration of study: Foundation University Medical College (FUMC) and Fauji Foundation Hospital (FFH), Rawalpindi, from March to December, 2006

Materials & Methods: 164 routinely processed liver biopsies were assessed and scored for grading (necro-inflammatory changes) & staging  (fibrosis) using modified Knodell HAI scoring system

Results: Our patients were mostly females and maximum cases were in 4th & 5th decades. Mild portal inflammation was seen in 78% and moderate in 20 % cases. Piecemeal necrosis was mild in 76% while moderate in 15% cases. HAI grades ranged from mild (161 cases) to moderate (03 cases). Fibrous portal expansion/short fibrous septae were seen in 35(21.3%) cases.  

Conclusion: HCV related liver disease is mild in our set up and a long term follow up of these cases is required to assess the progression of disease.

Key Words: Hepatitis, Hepatitis C virus, liver biopsy, Histological activity index, Knodell HAI scoring

Objective: To determine the morphological patterns of HCV related liver disease in our set up

Design: A cross sectional, descriptive study

Place & duration of study: Foundation University Medical College (FUMC) and Fauji Foundation Hospital (FFH), Rawalpindi, from March to December, 2006

Materials & Methods: 164 routinely processed liver biopsies were assessed and scored for grading (necro-inflammatory changes) & staging  (fibrosis) using modified Knodell HAI scoring system

Results: Our patients were mostly females and maximum cases were in 4th & 5th decades. Mild portal inflammation was seen in 78% and moderate in 20 % cases. Piecemeal necrosis was mild in 76% while moderate in 15% cases. HAI grades ranged from mild (161 cases) to moderate (03 cases). Fibrous portal expansion/short fibrous septae were seen in 35(21.3%) cases.  

Conclusion:HCV related liver disease is mild in our set up and a long term follow up of these cases is required to assess the progression of disease  

Key Words: Hepatitis, Hepatitis C virus, liver biopsy, Histological activity index, Knodell HAI scoring.

 

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Published

03-08-2016

How to Cite

1.
Kazi F, Ahmad M, Khan MA, Luqman M. MORPHOLOGICAL SPECTRUM OF CHRONIC HEPATITIS “C” INFECTION: EXPERIENCE AT FOUNDATION UNIVERSITY MEDICAL COLLEGE AND FAUJI FOUNDATION HOSPITAL RAWALPINDI. Pak J Pathol [Internet]. 2016 Aug. 3 [cited 2024 Apr. 16];20(2). Available from: http://pakjpath.com/index.php/Pak-J-Pathol/article/view/254

Issue

Vol. 20 No. 2 (2009)

Section

Articles

License

Copyright (c) 2016 Faiza Kazi, Mumtaz Ahmad, Masood Ahmad Khan, Muhammad Luqman

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