Analysis of the underlying pathological lesions in Hysterectomy specimens

Abstract

Objective: To see the types and frequency of pathological lesions in hysterectomy specimens. Materials and methods: This was a retrospective study conducted at the Department of Pathology, Basic Medical Sciences Institute, Jinnah postgraduate medical centre Karachi. A total of 1832 hysterectomy specimens over a period of 10 years, from January 1995 to December 2004 were reviewed. H and E slides studied to determine the type and frequency of malignant and benign lesions. Special stains were performed whenever required. Results: Out of 1832 cases of hysterectomies, 1724(94.1%) cases were diagnosed as benign and 79(4.3%) were malignant lesions, the remaining 29(1.6%) cases found to have no remarkable pathologic change. The benign lesions included leiomyoma 510(27.8%), adenomyosis 375(20.5%), leiomyoma with adenomyosis 284(15.8%) and other benign conditions. Malignant lesions included carcinoma 64(3.5%) and sarcoma 15(0.81%). Conclusion: The commonest benign lesion was found to be leiomyoma and the commonest uterine malignancy was adenocarcinoma of endometrium.